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Test Profane Jeevan

Abstract

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Introduction

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Research Ques & Method

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Results & Discussion

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Screenshot (3).png
Figure 1
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Conclusion

Brest 


TEST


PATIENT VALUE

REFERENCE RANGE

TSH


0.1µIU/mL

0.42-4.2µIU/mL

FreeT4


0.5ng/dL

0.8-1.8ng/dL


Prolactin


20.423ng/mL

3.8–23 ng/mL


FSH


2.76mIU/mL

2.5-16.7 mIU/mL


LH


0.1mIU/mL

0.6–56mIU/mL


Sr.Cortisol(PM)


0.8µg/dL

2.9–17.3 µg/dL


Sr.ACE


45.9

12–68U/L

IgG4-related hypophysitis is a rare but increasingly recognized inflammatory pituitary disorder with few cases reported previously. The clinical presentation is not very classical and similar to that for other inflammatory conditions of the pituitary. Imaging is not definitive and very similar to pituitary adenomas. Biopsy is confirmatory but considering the risks involved in a transsphenoidal biopsy or resection, it is important to identify and diagnose the inflammatory conditions so as to avoid invasive diagnostic procedures as well as to avoid long-term hormone replacement therapies. This relies on recognition of imaging patterns and clinical features, and having knowledge of alternative ways to confirm the diagnosis. As in this case, we avoided a biopsy with timely diagnosis, positive serology and early intervention.[3.4.5.6]

Diagnosis was confirmed as she responded well to glucocorticoids as reflected in follow up scans.

References

Wang Y, Zhang J, Chen Y, Wang C, Zhang Y, Pan J, et al. Clinical characteristics of 76 patients with IgG4-related hypophysitis: a systematic literature review. Int J Endocrinol. 2019;2019:5087012. doi:10.1155/2019/5087012. 1-Decker L, Klinger C, Jurk S, Christians A, Mawrin C, Buslei R, et al. IgG4-related hypophysitis: critical review of clinicopathological features and diagnostic criteria. Pituitary. 2017;20(6):684-691. doi:10.1007/s11102-016-0789-6. 2:Deshpande V, Zen Y, Chan JK, et al. Consensus statement on the pathology of IgG4-related disease. Modern Pathology. 2012;25(9):1181–1192. 3*Shikuma J, Oyama K, Nishioka H, Takeuchi Y, Takahashi JA. IgG4-related hypophysitis: a retrospective cohort study of eight biopsy-proven cases over 14 years at a single center. Acta Neurochir (Wien). 2022;164(7):1939-1949. doi:10.1007/s00701-022-05178-2. 4~Caturegli P, Newschaffer C, Olivi A, Pomper MG, Burger PC, Rose NR. Rituximab therapy for IgG4-related hypophysitis: a case series and literature review. J Endocr Soc. 2020;4(11):bvaa135. doi:10.1210/jendso/bvaa135.
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